|
KMID : 0387420040150020103
|
|
Korean Society of Oriental Neuropsychiatry
2004 Volume.15 No. 2 p.103 ~ p.118
|
|
|
The Effects of KongJin-Dan(KJD) on the Alzheimer’s Disease Model Induced by CT105
|
|
Chung Dae-Kyoo
Hwang Sun-Mi
|
|
|
Abstract
|
|
|
Objective:This experiment was designed to investigate the effect of KongJin-dan(KJD) on the Alzheimer’s disease.
Method:The effects of KJD on $LI-1{\beta}$, IL-6, $TNF-{\alpha}$, amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 and THP-1 cell treated by CT105 and AChE activity, APP production of PC-12 cell lysate treated by CT105 were investigated, respectively.
Results:1. KJD suppressed $LI-1{\beta}$, IL-6, $TNF-{\alpha}$, APP, AChE, GFAP mRNA in THP-1 and PC-12 cell treated by CT105. 2. KJD suppressed AChE activity and production of APP significantly in cell lysate of PC-12 cell treated by CT105.
Conclusion: This study shows that KJD might be usefully applied for prevention and treatment of Alzheimer’s disease.
|
|
|
KEYWORD
|
|
|
KongJin-dan(KJD), Alzheimer’s disease, CT105
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|